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Pitstop 2 (b)

CAS No. 1419093-54-1

Pitstop 2 (b)( Pitstop-2 | Pitstop2 )

Catalog No. M11752 CAS No. 1419093-54-1

A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pitstop 2 (b)
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis.
  • Description
    A small molecule inhibitor of clathrin terminal domain and inhibits clathrin-mediated endocytosis; inhibits endocytosis of transferrin receptor, a CDE cargo protein, but not affect endocytosis of shiga toxin; traps HeLa cells in metaphase through loss of mitotic spindle integrity and activation of the spindle assembly checkpoint, a useful tool for investigating clathrin spindle dynamics.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Pitstop-2 | Pitstop2
  • Pathway
    Others
  • Target
    Clathrin
  • Recptor
    Clathrin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1419093-54-1
  • Formula Weight
    473.36
  • Molecular Formula
    C20H13BrN2O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)C(=CC4=CC=C(C=C4)Br)S3
  • Chemical Name
    (Z)-N-(5-(4-bromobenzylidene)-4-oxo-4,5-dihydrothiazol-2-yl)naphthalene-1-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dutta D, et al. PLoS One. 2012;7(9):e45799. 2. Smith CM, et al. Mol Cancer. 2013 Jan 17;12:4. 3. Liashkovich I, et al. Sci Rep. 2015 May 6;5:9994. 4. Willox AK, et al. Biol Open. 2014 Apr 4;3(5):326-31.
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